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A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
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What every intensivist should know about exertional heat stroke
Niccolò Stomeo1, Laura Leuci1, Paolo Emilio Adami2
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Journal of Critical Care
|June 4, 2025
Summary
Exertional heat stroke (EHS) is a dangerous condition from intense exercise. Rapid cooling, like cold-water immersion, is vital for survival and preventing organ damage.
Area of Science:
- Emergency Medicine
- Sports Medicine
- Environmental Health
Background:
- Exertional heat stroke (EHS) is a severe hyperthermia and central nervous system dysfunction resulting from strenuous physical activity.
- EHS can affect young, healthy individuals even in temperate climates due to a failure in thermoregulation.
- Increasing global temperatures and endurance event participation are linked to a rise in EHS cases.
Purpose of the Study:
- To provide intensivists with practical guidance on the pathophysiology, diagnosis, and management of exertional heat stroke.
- To emphasize the critical role of intensivists in early intervention and improving patient outcomes for EHS.
- To highlight the importance of awareness and preparedness in managing the growing incidence of EHS.
Main Methods:
- This review synthesizes current knowledge on EHS pathophysiology and clinical management.
- It focuses on diagnostic criteria and emphasizes immediate cooling strategies.
- The review discusses in-hospital care, including managing complications and supportive treatments.
Main Results:
- Early recognition and rapid cooling, particularly whole-body cold-water immersion, are crucial for survival.
- The "cool first, transport second" approach is essential for effective EHS management.
- Prompt in-hospital care is necessary to manage potential multi-organ complications.
Conclusions:
- Intensivists play a pivotal role in reducing EHS morbidity and mortality through timely intervention.
- Effective management requires a thorough understanding of EHS pathophysiology and prompt application of cooling therapies.
- Increased awareness and preparedness are essential to address the rising incidence of exertional heat stroke and improve patient outcomes.
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