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M-Cdk Drives Transition Into Mitosis

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Related Experiment Video

Updated: Sep 19, 2025

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

CDKL3, a versatile kinase with increasing recognition.

Lanjing Ma¹, Haijiao Zhang¹, Zhongqiu Pang¹

¹College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China.

Biochemical and Biophysical Research Communications

|June 4, 2025

Summary

This summary is machine-generated.

Cyclin-Dependent Kinase-Like 3 (CDKL3) plays a key role in cell cycle regulation and metabolic diseases. Recent studies reveal its pivotal functions in cancer initiation and progression, warranting further investigation.

Keywords:

Akt CDKL3 Cell cycle Metabolism Oncogene ccRCC

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Last Updated: Sep 19, 2025

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

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Published on: June 30, 2019

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Area of Science:

Molecular Biology
Biochemistry
Oncology

Background:

Cyclin-Dependent Kinase-Like 3 (CDKL3) is a serine/threonine kinase in the CDKL family, identified in 1999.
Despite structural similarities to MAPK and CDK, CDKL3's functions have been historically under-explored.
Previous research indicated CDKL3 involvement in cell cycle regulation and cancer, but mechanisms remain unclear.

Purpose of the Study:

To comprehensively review the molecular mechanisms, functions, and protein interactions of CDKL3.
To elucidate the pivotal role of CDKL3 in cell cycle regulation, metabolic disease, and cancer.
To discuss future research perspectives for CDKL3.

Main Methods:

Systematic review of existing literature on CDKL3.
Analysis of CDKL3's molecular structure and sequence homology.
Integration of recent findings on CDKL3's physiological roles.

Main Results:

CDKL3 is confirmed to be pivotal in cell cycle regulation.
CDKL3 significantly impacts metabolic disease development.
CDKL3 plays a crucial role in cancer initiation and progression.

Conclusions:

CDKL3 is a key regulator with significant implications in cell cycle control and metabolic health.
Further research into CDKL3's mechanisms is essential for understanding and potentially treating cancer.
CDKL3 represents a promising target for future therapeutic strategies.