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Experimental production of arachnoiditis with water-soluble myelographic media
Abstract:
After myelography with either metrizamide (300mg l/ml) or meglumine iocarmate (280 mg l/ml), mild to severe arachnoid fibrosis was demonstrated radiographically and histologically in primates. Intrathecal injections of metrizamide (170 mg l/ml) or autologous cerebrospinal fluid produced less arachnoiditis. The risk of arachnoiditis is probably minimized by the use of reduced volumes and concentrations of water-soluble media. Controlled studies of arachnoiditis following myelography are probably more reliable in the primate model than in other experimental animals.
Insights
Myelography using metrizamide or meglumine iocarmate in primates can cause arachnoid fibrosis. Lower concentrations and volumes of water-soluble contrast media may minimize the risk of arachnoiditis.
Area of Science:
- Radiology and Imaging
- Neuroscience
- Comparative Pathology
Background:
- Myelography is a diagnostic imaging procedure used to visualize the spinal canal.
- Water-soluble contrast media are commonly employed, but potential adverse effects like arachnoiditis are a concern.
Purpose of the Study:
- To evaluate the risk of arachnoiditis following myelography with different contrast agents and concentrations in a primate model.
- To determine factors influencing the development of arachnoid fibrosis after myelography.
Main Methods:
- Primates underwent myelography using metrizamide or meglumine iocarmate at specified concentrations.
- Radiographic and histological analyses were performed to assess the degree of arachnoid fibrosis.
- Comparative analysis included intrathecal injections of lower concentration metrizamide and autologous cerebrospinal fluid.
Main Results:
- Mild to severe arachnoid fibrosis was observed after myelography with higher concentrations of metrizamide and meglumine iocarmate.
- Lower concentrations of metrizamide and autologous cerebrospinal fluid resulted in less pronounced arachnoiditis.
- The primate model demonstrated reliability for controlled studies on myelography-induced arachnoiditis.
Conclusions:
- The risk of arachnoiditis following myelography is associated with the concentration and volume of water-soluble contrast media used.
- Reducing contrast agent concentration and volume may mitigate the incidence and severity of arachnoid fibrosis.
- Primates serve as a suitable model for investigating arachnoiditis complications of myelography.