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Updated: Jan 18, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Cancer-related fatigue
Dori Beeler1,2, Bernadette Brady3,4, Declan Walsh5,2
1Department of Supportive Oncology, Atrium Health Levine Cancer Institute, Charlotte, North Carolina, USA dori.beeler@atriumhealth.org.
Abstract:
Cancer-related fatigue (CRF) is a major clinical problem. This paper integrates the evidence-based literature and professional guidelines to support a proposed systematic approach to CRF diagnosis and management. This approach includes four diagnostic criteria, six steps for routine care and two major evidence-based treatment modalities. These comprise non-pharmacological and pharmacological interventions. This approach can reduce CRF management barriers while highlighting the illness trajectory phase when specific interventions will be most effective.
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