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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Protocol for a global menopause priority setting partnership.

Zachary Nash1, Monica M Christmas2, Toto Gronlund3

  • 1Institute for Women's Health, UCL, London, UK z.nash@ucl.ac.uk.

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|June 4, 2025
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Summary
This summary is machine-generated.

This study identified key research priorities for menopause care by engaging global experts and individuals with lived experience. The findings will shape future menopause research agendas to address existing evidence gaps.

Keywords:
GYNAECOLOGYGeneral endocrinologyReproductive medicine

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Area of Science:

  • Women's Health
  • Endocrinology
  • Public Health Research

Background:

  • Menopause affects all individuals with ovaries, often causing symptoms, yet significant gaps exist in evidence-based care.
  • The National Institute for Health and Care Research James Lind Alliance Menopause Priority Setting Partnership (MAPS) aims to address these knowledge deficits.

Purpose of the Study:

  • To engage global clinicians and individuals with lived experience to identify and prioritize future research needs in menopause care.
  • To establish a consensus on the leading priorities for menopause research.

Main Methods:

  • The James Lind Alliance methodology was employed, involving a steering group of clinicians and lived experience members.
  • Evidence uncertainties were identified via an online survey, followed by evidence checking to ascertain existing research.
  • Prioritization occurred in two stages: an initial online survey and a final face-to-face consensus workshop.

Main Results:

  • The study successfully identified and ranked the top 10 research priorities for menopause care through stakeholder consensus.
  • These priorities were determined by a combination of expert opinion and lived experience input.

Conclusions:

  • The identified top 10 priorities will guide the future global research agenda for menopause.
  • Dissemination will occur through peer-reviewed journals and publicly available reports to inform research and clinical practice.