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Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats.

J St-Louis, G Massicotte

    Life Sciences
    |October 7, 1985
    PubMed
    Summary
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    Relaxin, a hormone crucial during rat gestation, significantly lowers blood pressure in spontaneously hypertensive rats (SHR). This hormone did not affect blood pressure in control rats, suggesting a specific role in hypertension regulation.

    Area of Science:

    • Reproductive Endocrinology
    • Cardiovascular Physiology

    Background:

    • Relaxin is an ovarian hormone abundant in late-term pregnant rats.
    • A notable decline in blood pressure occurs during this period, particularly in spontaneously hypertensive rats (SHR).

    Purpose of the Study:

    • To investigate the potential role of relaxin in the gestation-induced decrease in blood pressure.
    • To determine if exogenous relaxin administration can reduce blood pressure in hypertensive rat models.

    Main Methods:

    • Intravenous infusion of purified rat relaxin and porcine relaxin into female non-pregnant rats using osmotic mini pumps.
    • Monitoring of systolic blood pressure in SHR and control Wistar-Kyoto rats (WKY) over several days.

    Main Results:

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  • Rat relaxin infusion significantly reduced systolic blood pressure in SHR within 24 hours, lasting for at least 5 days.
  • Porcine relaxin also lowered blood pressure in SHR, but with a delayed and less pronounced effect.
  • No significant blood pressure changes were observed in WKY rats treated with rat relaxin.

    • Conclusions:

    • Relaxin plays a significant role in the regulation of blood pressure, particularly in the context of hypertension.
    • The findings support the hypothesis that relaxin contributes to the blood pressure reduction observed during gestation.