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Tetrahydrofuran-Containing Pharmaceuticals: Targets, Pharmacological Activities, and their SAR Studies
1School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, P. R. China.
Abstract:
Tetrahydrofuran (THF), a five-membered cyclic ether with a carbon-oxygen ring structure, is a common solvent and an important functional group in the field of organic synthesis methodology. In addition, THF also plays an important role in drug discovery. The US food and drug administration (FDA) has approved a total of 13 THF-containing drugs for a range of clinical diseases, such as Terazosin and Darunavir. These drugs exhibit superior pharmacological effects in multiple therapeutic fields. This review offers an extensive overview of FDA-approved drugs containing the THF nucleus, emphasizing their pharmacological activities and structure-activity relationships.
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