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Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Apr 22, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Expression of serum HMGB1, SAA, and TSGF in patients with colon cancer and the value of prognostic assessment.

Kaifeng Wang1, Junxing Huang2

  • 1The Affiliated Taizhou People's Hospital of Nanjing University of Chinese Medicine China, Taizhou, Jiangsu, P. R. China.

Cancer Biomarkers : Section a of Disease Markers
|June 5, 2025
PubMed
Summary

Serum levels of high mobility group protein 1 (HMGB1), amyloid A (SAA), and tumor-specific growth factor (TSGF) are elevated in colon cancer (CRC) patients. These markers, especially when combined, show significant potential for assessing CRC prognosis and disease progression.

Keywords:
HMGB1SAATNM stageTSGFcolon cancerdegree of differentiationlymph node metastasisprognosis

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Gastroenterology

Background:

  • Colon cancer (CRC) poses a significant global health challenge, necessitating improved diagnostic and prognostic tools.
  • Early detection and accurate prognosis are crucial for effective CRC management and patient outcomes.
  • Identifying reliable biomarkers can aid in stratifying patients and guiding treatment strategies.

Purpose of the Study:

  • To investigate the expression levels of serum high mobility group protein 1 (HMGB1), amyloid A (SAA), and tumor-specific growth factor (TSGF) in colon cancer (CRC) patients.
  • To evaluate the prognostic value of these biomarkers in CRC patients.
  • To compare the expression of HMGB1, SAA, and TSGF in CRC patients with those suffering from inflammatory bowel disease (IBD) and healthy individuals.

Main Methods:

  • Serum samples were collected from 60 CRC patients, 60 IBD patients, and 60 healthy controls.
  • Levels of HMGB1, SAA, and TSGF were quantified using specific detection methods.
  • Association with clinical features (TNM stage, differentiation, lymph node metastasis) and prognosis was analyzed.
  • Receiver operating characteristic (ROC) curves were utilized to assess the predictive value of the biomarkers.

Main Results:

  • Serum HMGB1, SAA, and TSGF levels were significantly elevated in CRC patients compared to IBD patients and healthy controls (P<0.05).
  • Higher levels of these biomarkers correlated with advanced TNM stage, poor differentiation, and lymph node metastasis in CRC patients (P<0.05).
  • Patients with a poor prognosis exhibited significantly higher serum HMGB1, SAA, and TSGF levels than those with a good prognosis (P<0.05).
  • The combined analysis of HMGB1, SAA, and TSGF demonstrated a high area under the curve (AUC) of 0.903 for predicting CRC prognosis, outperforming individual markers.

Conclusions:

  • Serum HMGB1, SAA, and TSGF are significantly upregulated in colon cancer patients.
  • These biomarkers serve as valuable indicators of CRC progression, correlating with tumor stage, differentiation, metastasis, and patient prognosis.
  • The combined assessment of HMGB1, SAA, and TSGF offers a promising tool for prognostic evaluation in CRC.