Related Experiment Video
Updated: May 4, 2026

13:51
Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
Published on: November 10, 2017
15.5K
Enhancing the CuAAC efficiency of a Cu(I)-NHC complex in biological media by encapsulation
A P Prakasham1, Harshit Singh1, Anja R A Palmans1
1Department of Chemical Engineering & Chemistry and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. a.palmans@tue.nl.
Abstract
None:
A novel [(NHC)2Cu]Br (Cu(I)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.

