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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Neurological Inflammation in Parkinsonism: Current Prognosticative Diagnostics and Pitfalls
Thangavel Lakshmipriya1, Subash C B Gopinath2,3,4, Yeng Chen5
1Center for Global Health Research, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India.
Researchers are exploring advanced biosensors to detect Parkinson's disease (PD) biomarkers. These diagnostic tools aim for early detection and personalized treatment to slow PD progression.
Area of Science:
- Neuroscience
- Biomarker Discovery
- Diagnostic Technologies
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting dopamine-producing neurons in the substantia nigra.
- PD impacts central nervous system function, leading to neurotransmitter deficiencies like norepinephrine.
- Clinical symptoms include fatigue, gait issues, rigidity, and olfactory loss, significantly impairing daily life.
Purpose of the Study:
- To review the performance of diagnostic biomarkers for Parkinson's disease.
- To emphasize the effectiveness of immuno-, apta-, and DNA-sensors for biomarker detection.
- To discuss the advantages and disadvantages of various detection methods for improved diagnostics.
Main Methods:
- Review of current literature on Parkinson's disease biomarkers.
- Analysis of sensor technologies including immuno-, apta-, and DNA-sensors.
- Evaluation of diagnostic methods for biomarker detection and PD diagnosis.
Main Results:
- Diagnostic biomarkers show strong performance in identifying Parkinson's disease.
- Immuno-, apta-, and DNA-sensors are effective for implementing various biomarker detection strategies.
- Current FDA-approved methods like DATscan-SPECT offer precise analysis.
Conclusions:
- Advanced biosensors and biomarkers are crucial for early and accurate Parkinson's disease diagnosis.
- Personalized treatment strategies can be recommended based on biomarker detection.
- Continued research into detection methods is vital for enhancing diagnostic performance and patient outcomes.
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