Natural Hydrazone Derivatives: Their Sources, Structures, and Bioactivities.
Hagar M Mohamed1,2, Hazem G A Hussein3, Gamal A Mohamed4
1Department of Medical Laboratory Analysis, College of Medical & Health Sciences, Liwa University, Abu Dhabi 41009, United Arab of Emirates.
Mini Reviews in Medicinal Chemistry
|June 5, 2025
Summary
Natural hydrazone derivatives from diverse sources exhibit significant biological activities. This review highlights their therapeutic potential in drug discovery and pharmaceutical research.
Area of Science:
- Medicinal Chemistry
- Natural Product Chemistry
- Pharmacology
Background:
- Hydrazone-containing compounds are recognized for their diverse bioactivities.
- Natural hydrazone derivatives are isolated from various organisms like bacteria, plants, fungi, and marine life.
- These compounds possess unique chemical structures contributing to their biological effects.
Purpose of the Study:
- To comprehensively review natural hydrazone derivatives published between 1967 and March 2025.
- To detail the sources, structural characteristics, and biological activities of these compounds.
- To assess the therapeutic potential of natural hydrazones in pharmaceutical research.
Main Methods:
- Literature search of scientific databases for relevant studies.
- Systematic review and analysis of published data on natural hydrazone derivatives.
- Compilation of information on 72 distinct compounds and 75 cited references.
Main Results:
- Identification and characterization of 72 natural hydrazone derivatives from various sources.
- Detailed documentation of structural features and associated biological activities.
- Summary of findings spanning nearly six decades of research.
Conclusions:
- Natural hydrazone derivatives represent a promising class of compounds for drug discovery.
- Their diverse biological activities underscore their therapeutic potential.
- Further research into these compounds could lead to novel pharmaceutical applications.
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