Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of Tourniquet Release: A Prospective Randomized Trial.

Hand (New York, N.Y.)·2026
Same author

Atypical ocular and vascular manifestations of <i>Klebsiella</i> liver abscess syndrome.

Radiology case reports·2026
Same author

Unusual Gastrointestinal Bleeding due to an Aberrant Artery Neighboring a Jejunal Gastrointestinal Stromal Tumor.

ACG case reports journal·2026
Same author

Regenerative peripheral nerve interfaces (RPNIs) and implanted electrodes improve online control of prostheses for hand and wrist<sup></sup>.

Journal of neural engineering·2026
Same author

A Sub-mm<sup>3</sup> Wireless Neural Stimulator IC for Visual Cortical Prosthesis With Optical Power Harvesting and 7.5-kb/s Data Telemetry.

IEEE journal of solid-state circuits·2025
Same author

Altered lipid metabolism and inflammatory programs associate with adipocyte loss in familial partial lipodystrophy 2.

The Journal of clinical investigation·2025

Related Experiment Video

Updated: Jun 17, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat
10:35

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat

Published on: February 25, 2020

8.2K

A Robust Neuromuscular Interface to Restore Lost Function in People with Amputations.

Alex Vaskov1, Dylan Wallace1, Karan Desai1

  • 1University of Michigan-Ann Arbor.

Research Square
|June 5, 2025
PubMed
Summary

Regenerative Peripheral Nerve Interfaces (RPNIs) offer a viable solution for upper limb prosthetics. This early trial shows RPNI implantation reliably records nerve signals for advanced prosthetic control.

More Related Videos

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers
07:59

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers

Published on: October 29, 2021

3.4K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.0K

Related Experiment Videos

Last Updated: Jun 17, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat
10:35

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat

Published on: February 25, 2020

8.2K
Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers
07:59

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers

Published on: October 29, 2021

3.4K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.0K

Area of Science:

  • Biomedical Engineering
  • Neuroprosthetics
  • Regenerative Medicine

Background:

  • Upper limb loss significantly impairs daily activities and well-being.
  • Current prosthetic control interfaces lack the dexterity of multi-articulating robotic hands.
  • Sensing motor signals from peripheral nerves is challenging after muscle loss due to amputation or injury.

Purpose of the Study:

  • To evaluate the feasibility and safety of implanting Regenerative Peripheral Nerve Interfaces (RPNIs) with intramuscular electrodes.
  • To assess the quality of control signals recorded from RPNIs for prosthetic applications.
  • To develop algorithms for predicting intended movements using RPNI signals.

Main Methods:

  • An early-feasibility clinical trial involving four patients with upper limb loss.
  • Implantation of intramuscular electrodes within RPNIs.
  • Recording of efferent motor action potentials from peripheral nerves.
  • Development of a predictive movement algorithm based on recorded signals.

Main Results:

  • RPNI implantation was a repeatable and viable technique in all four patients.
  • Electrodes recorded large-amplitude, stable control signals with a median Signal-to-Noise Ratio (SNR) of 40.6.
  • No serious adverse events were associated with the RPNI implantation or devices.
  • Valuable data was obtained for creating a movement prediction algorithm.

Conclusions:

  • RPNI-electrode implantation is a safe and effective method for capturing peripheral nerve signals.
  • This technique shows promise for enabling more intuitive and dexterous prosthetic limb control.
  • RPNIs represent a significant advancement in neuroprosthetic technology for individuals with limb loss.