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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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Magnolol improves postoperative cognitive dysfunction in aged mice by activating the nuclear factor erythroid

Jingwen Hao¹, Qi Wan, Yuan Liu

¹Department of Neurology, The First Hospital of Changsha, Changsha, Hunan, China.

|June 5, 2025

Summary

Magnolol effectively improved cognitive function in aged mice with postoperative cognitive dysfunction (POCD). This natural compound protected neurons and reduced inflammation by activating the Nrf2/ARE pathway.

Keywords:

Nrf2/ARE pathway aged mice magnolol neuroprotection postoperative cognitive dysfunction

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Area of Science:

Neuroscience
Pharmacology
Gerontology

Background:

Postoperative cognitive dysfunction (POCD) is prevalent in elderly patients, increasing mortality.
Magnolol shows potential for cognitive improvement, but its role in POCD is not well understood.

Purpose of the Study:

To investigate the therapeutic effects of magnolol on POCD in an aged mouse model.
To elucidate the underlying mechanisms involving the Nrf2/ARE pathway.

Main Methods:

An aged mouse model of POCD was induced using sevoflurane anesthesia and surgery.
Magnolol was administered at 10 or 20 mg/kg daily, starting one week pre-surgery.
Nrf2 knockdown mice were used to assess the Nrf2/ARE pathway's role.

Main Results:

Magnolol significantly improved cognitive performance, including memory and recognition.
It protected hippocampal neuron morphology, reduced apoptosis, and modulated inflammatory markers.
Magnolol activated the Nrf2/ARE pathway, and Nrf2 silencing diminished its beneficial effects.

Conclusions:

Magnolol demonstrates significant therapeutic potential for POCD in aged mice.
The Nrf2/ARE pathway is crucial for magnolol's neuroprotective and cognitive-enhancing effects in POCD.