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Exercise Prescription in Arrhythmogenic Cardiomyopathy: Finding the Right Balance Between Risks and Benefits

Lorenzo-Lupo Dei1,2, Jennie Han3, Silvio Romano1

  • 1Department of Life, Health and Environmental Sciences University of L'Aquila Italy.

Journal of the American Heart Association
|June 5, 2025
PubMed

Insights

Intense exercise may worsen arrhythmogenic cardiomyopathy (ACM) by increasing ventricular arrhythmias. This review examines exercise safety and prescription for ACM patients, focusing on risks associated with high-intensity physical activity.

Area of Science:

  • Cardiology
  • Genetics
  • Sports Medicine

Background:

  • Arrhythmogenic cardiomyopathy (ACM) is an inherited heart condition.
  • It is characterized by fibrofatty myocardial replacement, leading to potentially fatal arrhythmias.
  • ACM is a common cause of sudden cardiac death in young individuals and athletes.

Purpose of the Study:

  • To review current evidence on the safety and effects of exercise in ACM patients.
  • To examine research on the detrimental role of intense exercise in ACM.
  • To discuss exercise prescription guidelines for individuals with ACM.

Main Methods:

  • Review of existing research findings from animal and human models.
  • Analysis of studies on exercise's impact on ACM phenotype and arrhythmia propensity.
  • Examination of current knowledge on exercise recommendations for ACM.

Main Results:

  • Intense exercise may accelerate ACM progression and increase arrhythmia risk.
  • Evidence suggests a potential detrimental role of high-intensity physical activity in ACM.
  • Optimal exercise prescription for ACM patients requires careful consideration.

Conclusions:

  • While regular exercise benefits the general population, intense exercise poses risks for ACM patients.
  • Further research is needed to establish safe and effective exercise guidelines for ACM.
  • Personalized exercise recommendations are crucial for managing ACM and preventing sudden cardiac death.

Keywords:
arrhythmogenic cardiomyopathycardiomyopathiesdeath, sudden, cardiacexercise

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