Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.6K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.6K
DNA as a Genetic Template02:05

DNA as a Genetic Template

22.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
22.9K
The DNA Helix01:07

The DNA Helix

25.7K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
25.7K
Diffusion01:21

Diffusion

5.3K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
5.3K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

54.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
54.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging the flat bands of magic-angle graphene reshaped by interactions.

Nature·2026
Same author

Revealing Electron-Electron Interactions in Graphene at Room Temperature with a Quantum Twisting Microscope.

Nano letters·2026
Same author

Optical control over topological Chern number in moiré materials.

Nature·2026
Same author

Observation of a superfluid-to-insulator transition of bilayer excitons.

Nature·2026
Same author

Radio-Frequency Charge Detection on Graphene Electron-Hole Double Quantum Dots.

Nano letters·2025
Same author

Milli-Tesla quantization enabled by tuneable Coulomb screening in large-angle twisted graphene.

Nature communications·2025
Same journal

Formation of Bimetallic Nanoparticles via Exsolution Using a Reducible Metal Oxide Capping Layer.

ACS nano·2026
Same journal

Cold-Driven Thermoelectric Patch for Postoperative Tumor Control.

ACS nano·2026
Same journal

Chemically Fueled Interfacial Supramolecular Polymerization.

ACS nano·2026
Same journal

Tactile Neuromorphic Ion-Gated Vertical Transistor Displays Enabling Dual-Output Reservoir Computing.

ACS nano·2026
Same journal

In Situ Oxygen Shuttling within a Bilayer Electrified Membrane Enables Aeration-Free Electro-Fenton Water Purification.

ACS nano·2026
Same journal

Single Atoms as Growth Directors: From Graphene Edges to Atomically Precise Interfaces in 2D Materials.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Sep 19, 2025

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
12:05

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

Published on: October 1, 2017

8.3K

Diffusion of DNA on Atomically Flat 2D Material Surfaces.

Dong Hoon Shin1,2,3, Sung Hyun Kim1,4,5, Kush Coshic6

  • 1Kavli Institute of Nanoscience Delft, Lorentzweg 1, 2628 CJ Delft, The Netherlands.

ACS Nano
|June 5, 2025
PubMed
Summary
This summary is machine-generated.

Researchers explored DNA molecule interactions with hexagonal boron nitride (hBN) surfaces. They found DNA diffusion on hBN can be controlled by DNA length, surface features, and defects, enabling potential nanofluidic applications.

Keywords:
DNAhexagonal boron nitridenanofluidicssurface diffusionvan der Waals materials

More Related Videos

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.7K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.6K

Related Experiment Videos

Last Updated: Sep 19, 2025

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
12:05

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

Published on: October 1, 2017

8.3K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.7K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.6K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Accurate localization and delivery of biomolecules are crucial for biological research tools.
  • Atomically flat 2D surfaces offer potential for biomolecule manipulation, but experimental realization has been challenging.

Purpose of the Study:

  • To comprehensively characterize the interactions of individual DNA molecules with hexagonal boron nitride (hBN) surfaces.
  • To investigate the controllable diffusion of DNA on hBN surfaces.
  • To explore the potential of hBN for nanofluidic guiding of biomolecules.

Main Methods:

  • Combined single-molecule detection methods with computational approaches.
  • Experimentally studied DNA molecule interactions with hBN surfaces.
  • Fabricated narrow hBN ribbon structures for confinement studies.

Main Results:

  • DNA molecules retain diffusion ability upon binding to hBN surfaces.
  • DNA diffusion magnitude and direction are controllable by DNA length, surface topography, and atomic defects.
  • Observed diffusion speeds were lower than predicted by simulations, explained by a temporary trapping model.
  • Achieved pseudo-1D confinement using hBN ribbon structures.

Conclusions:

  • Hexagonal boron nitride surfaces provide a platform for controlled biomolecule diffusion.
  • Atomic defects on hBN surfaces play a significant role in modulating DNA diffusion.
  • hBN ribbon structures demonstrate potential for nanofluidic guiding of biomolecules.