Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving autotrophic D-lactate production by heterologous expression of a pyruvate formate lyase in an LDHD-expressing Acetobacterium woodii strain.

Applied microbiology and biotechnology·2026
Same author

Regioselective Oxidation of D-Galacturonic Acid to Provide Crystallized Mucic Acid Using Engineered <i>Gluconobacter oxydans</i>.

Biotech (Basel (Switzerland))·2026
Same author

Careful CO Addition Enhances Autotrophic d-Lactate Formation With Engineered <i>Acetobacterium woodii</i>.

Engineering in life sciences·2026
Same author

Autotrophic and Mixotrophic Batch Processes with <i>Clostridium autoethanogenum</i> LAbrini in Stirred Tank Bioreactors with Continuous Gassing.

Microorganisms·2026
Same author

Monitoring of the Single-Cell Behavior of an <i>Escherichia coli</i> Reporter Strain Producing L-phenylalanine in a Scale-Down Bioreactor by Automated Real-Time Flow Cytometry.

Biotech (Basel (Switzerland))·2025
Same author

Application of a Rational Crystal Contact Engineering Strategy on a Poly(ethylene terephthalate)-Degrading Cutinase.

Bioengineering (Basel, Switzerland)·2025

Related Experiment Video

Updated: May 8, 2026

Comparison of Scale in a Photosynthetic Reactor System for Algal Remediation of Wastewater
05:40

Comparison of Scale in a Photosynthetic Reactor System for Algal Remediation of Wastewater

Published on: March 6, 2017

9.5K

Scale-down bioreactors-comparative analysis of configurations.

Prasika Arulrajah1,2, Anni Elina Lievonen3, Dilara Subaşı3

  • 1Chair of Biochemical Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748, Garching, Germany.

Bioprocess and Biosystems Engineering
|June 5, 2025
PubMed
Summary

Scale-down bioreactors help study large-scale bioprocess gradients (pH, dissolved oxygen, substrate) in the lab. Challenges include replicating real conditions and selecting the right bioreactor configuration for accurate results.

Keywords:
C. glutamicumE. coliS. cerevisiaeBioprocessBioreactorCHOFermentationGradientsScale-down

More Related Videos

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.4K
Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
09:28

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

9.2K

Related Experiment Videos

Last Updated: May 8, 2026

Comparison of Scale in a Photosynthetic Reactor System for Algal Remediation of Wastewater
05:40

Comparison of Scale in a Photosynthetic Reactor System for Algal Remediation of Wastewater

Published on: March 6, 2017

9.5K
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.4K
Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
09:28

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

9.2K

Area of Science:

  • Biotechnology
  • Biochemical Engineering

Background:

  • Large-scale bioprocesses face efficiency losses due to gradients in pH, dissolved oxygen (DO), and substrate concentrations.
  • Scale-down bioreactors offer a cost-effective lab-scale approach to investigate these critical gradients.

Purpose of the Study:

  • To review and compare various scale-down bioreactor configurations for studying large-scale bioprocess gradients.
  • To analyze the challenges and suitability of scale-down models for different cell types and bioprocesses.

Main Methods:

  • Review of existing literature on scale-down bioreactor technologies.
  • Characterization and comparison of different scale-down bioreactor types (e.g., stirred-tank, multi-compartment).
  • Analysis of bioprocess examples using microorganisms and mammalian cells.

Main Results:

  • Scale-down bioreactors present challenges in accurately mimicking large-scale gradient conditions.
  • Different scale-down configurations have distinct advantages and disadvantages.
  • Cellular responses to scale-down conditions vary, impacting bioprocess outcomes.

Conclusions:

  • Careful selection of scale-down bioreactor configurations is crucial for effective bioprocess optimization.
  • Understanding cellular responses to scale-down is key to interpreting results accurately.
  • Miniaturized and microfluidic bioreactors show future potential for scale-down studies.