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Correlation analysis between hemoglobin and type 2 diabetic nephropathy: a two-center retrospective study
Xiaoling Liu1, Ze Zhang2, Lu Lin1
1Fuzong Clinical Medical College of Fujian Medical University, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, China.
Low hemoglobin (Hb) levels are strongly linked to diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. This finding suggests Hb can serve as a predictive biomarker for DN development.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Diseases
Background:
- Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM).
- Understanding predictors of DN is crucial for early intervention and management.
Purpose of the Study:
- To investigate the association between hemoglobin (Hb) levels and the presence of DN in T2DM patients.
- To evaluate Hb as a potential predictive biomarker for DN.
Main Methods:
- Cross-sectional study involving 1956 T2DM patients from two centers.
- Clinical data analysis using binary logistic regression and restricted cubic spline (RCS) plots.
- Adjusted for potential confounding factors in the analysis.
Main Results:
- A significant inverse relationship was observed between Hb levels and DN.
- Patients in the lowest quartile of Hb had a higher prevalence of DN.
- Subgroup analyses showed no significant correlation between Hb, DN, and factors like hypertension or retinopathy.
Conclusions:
- Low Hb levels are closely associated with the occurrence of DN in T2DM.
- Hb can be utilized as a predictive biomarker for DN.
- Further research may elucidate the mechanisms underlying this association.
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