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COVID-19 detection in bone tissue after a new protocol for decellularize bone with sustained collagen matrix
Leticia Ramos Dantas1, Felipe Francisco Tuon2
1Laboratory of Emerging Infectious Diseases, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição 1155, Curitiba, PR, 80215-901, Brazil.
Abstract:
The transmissibility rate of the SARS-CoV-2 virus, which causes COVID-19, in organ and tissue donation is not known. Considering all issues related to the risk of SARS-CoV-2 transmission and the risk of tissue shortages due to donor exclusion, this in vitro study evaluated the detection of SARS-CoV-2 RNA in bone tissue models after bone processing for tissue bank. Bone processing has activity against SARS-CoV-2 and not RNA was detected in the end of the process. The use of bone tissue can be considered in case of shortage.
