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Updated: Sep 19, 2025

Chromatin Immunoprecipitation from Human Embryonic Stem Cells
Published on: July 22, 2008
The rebirth of repressive chromatin during early vertebrate development
Dilani Rajapakse-Yongue1, Mary Goll1
1Department of Genetics, University of Georgia, Athens, Georgia, USA.
Abstract:
Following fertilization, gamete-specific chromatin configurations must be reset to allow for the rebirth of an embryo-specific chromatin landscape capable of driving organismal development. During early cell divisions, the rebuilding of embryonic chromatin requires the renewed delineation of transcriptionally permissive and repressive chromatin states across the genome. This review summarizes our current understanding of how repressive chromatin states are reborn during vertebrate embryogenesis. We highlight both shared and divergent features across species, emphasizing well-characterized mouse and zebrafish models.
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