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Semaglutide Modulates Proinflammatory Epicardial Adipogenesis With Paracrine Effects on hiPSC-Atrial Cardiomyocytes

Rumeysa Basdas1, José Manuel Martínez-Cereijo2, Ángel L Fernández3

  • 1Translational Cardiology, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain; University of Santiago de Compostela, Santiago de Compostela, Spain.

JACC. Basic to Translational Science
|June 5, 2025
PubMed
Summary

Semaglutide, a glucagon-like peptide receptor agonist, reduces inflammation in epicardial fat (EAT) and impacts atrial cardiomyocytes. This finding offers new insights into cardiovascular disease risk management.

Keywords:
adipogenesisepicardial fatmetabolismsemaglutide

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