Experimental pulmonary nocardiosis in monkeys

The study describes an easy and reproducible technique of producing pulmonary nocardiosis in monkeys, yielding consistent morbidity and mortality results. Introduction of the fungal suspension into the lower canaliculus, with or without debridement of the canalicular epithelium, produced fatal pneumonitis in 1-2 weeks. Specificity of the lesions was determined by demonstration of Nocardia in tissue sections and in culture.