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Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease
Giovanni Santacroce1,2, Alessandro Vanoli3,4, Nicola Aronico2
1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
Introduction:
Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).
Methods:
We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.
Results:
CD-associated SBA showed a significantly ( P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA.
Discussion:
Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.
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