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Asthma: Biomedical and Psychobiological Perspectives.
Thomas Ritz1, Melissa A Rosenkranz, Juan C Celedón
1Department of Psychology, Southern Methodist University, Dallas, Texas, (Ritz); Center for Healthy Minds, and Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, (Rosenkranz); Department of Pediatrics, Division of Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, (Celedón); Department of Physiological Sciences, University of Florida, Gainesville, Florida, (Davenport); Faculty of Medicine, Clinical and Experimental Sciences and Human Development and Health, University of Southampton, and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK (Djukanovic); Ferkauf Graduate School of Psychology, Yeshiva University, and Department of Pediatrics, Division of Academic General Pediatrics, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York, New York, (Feldman); Department of Medicine, Division of Pulmonary Medicine, Alberta Respiratory Centre, University of Alberta, Edmonton, Canada (Forsythe); University of Wisconsin-Madison School of Medicine and Public Health, Pulmonary and Critical Care Division, Madison, Wisconsin, (Jajour); Department of Cellular and Molecular Medicine, Asthma and Airway Disease Research Center, BIO5 Institute, and Arizona Center for the Biology of Complex Diseases, University of Arizona, Tucson, Arizona, (Vercelli); Research Group Health Psychology, KU Leuven, Leuven, Belgium (von Leupoldt); Department of Environmental Medicine, Department of Public Health, and Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, (Wright).
Asthma research integrates biomedical and psychobiological insights, highlighting the need for further study on gene-microbiome-psychosocial interactions and brain-body connections for holistic treatment.
Area of Science:
- Integrative medicine
- Psychoneuroimmunology
- Asthma research
Background:
- Decades of biomedical and psychobiological research have advanced asthma understanding.
- Psychosocial factors significantly influence asthma development, pathophysiology, and management.
- Gaps remain in understanding gene-microbiome-psychosocial interactions in asthma.
Purpose of the Study:
- To report on synergistic perspectives from biomedical and psychobiological research on asthma.
- To identify areas for future research in asthma mechanisms and treatment.
- To promote an integrative, biopsychosocial approach to asthma care.
Main Methods:
- Discussion at the American Psychosomatic Society's first Annual Disease-A-Year Symposium.
- Review of progress in identifying asthma's mechanical, cellular, and molecular mechanisms.
- Exploration of psychosocial influences on asthma.
Main Results:
- Progress in understanding asthma mechanisms and psychosocial influences.
- Emerging focus on central nervous system effects and brain-body interaction in asthma.
- Recognition of societal factors impacting asthma disparities and resilience.
Conclusions:
- Further research is needed on gene-microbiome-psychosocial interactions and central nervous system effects.
- An integrative, biopsychosocial model is crucial for holistic asthma treatment.
- Interdisciplinary collaboration is essential for advancing asthma care and improving patient outcomes.
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