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Published on: August 5, 2014
Alterations in functional connectivity related to prognosis in unilateral sudden sensorineural hearing loss
Jin Sun1, Baohong Wen1, Zijun Liu1
1Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Objectives:
Sudden Sensorineural Hearing Loss (SSNHL) is a critical otological emergency characterized by a rapid decline in hearing, primarily affecting one ear. The exact cause of SSNHL remains unclear, which complicates both diagnosis and treatment. This study aimed to explore changes in functional connectivity (FC) related to prognosis in patients with unilateral SSNHL, thereby enhancing our understanding of the potential neural correlates associated with clinical outcomes.
Materials And Methods:
The study involved 111 patients diagnosed with unilateral SSNHL, who underwent audiological evaluations and functional magnetic resonance imaging (fMRI) scans, focusing on changes in FC related to their prognosis.
Results:
Significant differences were found between the effective (n = 72) and ineffective (n = 39) treatment groups regarding the duration from onset to treatment and the presence of dizziness. Compared with effective group, the cohort with a poor prognosis demonstrated a significant increase in FC between the bilateral superior temporal gyrus (STG) and the left hippocampus, right supramarginal gyrus (SMG), left middle frontal gyrus (MFG), and right precuneus.
Conclusion:
The research highlights the significance of investigating the alterations in FC observed in patients experiencing SSNHL. These findings suggest a potential association between altered FC and patient outcomes, which could contribute to future studies on the neural mechanisms underlying SSNHL.
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