Related Experiment Video
Updated: Jun 26, 2026
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Intravesical doxorubicin induced bladder contracture that led to cystectomy: a case series
Ahmed Aldolly1, Mohamad Yasin Lutfi2
1Faculty of Medicine, Hama University, Hama, Syria.
Introduction And Importance:
Doxorubicin is a popular anthracycline antibiotic that exerts its anticancer effects through various mechanisms. Treatment protocols typically involve an initial induction phase followed by a maintenance phase.
Case Series:
We present two cases (ages: 66, 75 years) with superficial transitional cell carcinoma of the bladder. They developed severe bladder contracture after transurethral resection of the bladder, followed by intravesical doxorubicin. Then required radical cystectomy and urinary diversion.
Clinical Discussion:
The intravesical instillation comes with the benefit of lower systemic side effects than systemic administration. Bladder contracture following intravesical doxorubicin is very rare.
Conclusion:
Severe bladder contracture is a very rare but serious side effect of intravesical therapy. This incident can affect the patient's quality of life and may even lead to cystectomy. Objective monitoring of bladder capacity is recommended for those patients.
More Related Videos
10:19Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
06:39Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
Published on: November 22, 2019
Related Concept Videos
01:25Urinary Tract Calculi VI: Surgical Management
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
01:28Urologic Endoscopic Procedure: Cystoscopic Examination