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Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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Updated: May 6, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Advanced microneedle arrays for transdermal antibiotic delivery.

Vishin Patil¹, Pooja S Patil², Mugdha Vasant Kulkarni²

¹Bharati Vidyapeeth College of Pharmacy Kolhapur: Kolhapur, Maharashtra, India.

Current Opinion in Pharmacology

|June 5, 2025

Summary

Microneedle (MN) arrays offer a promising alternative to traditional antibiotic delivery, improving drug penetration and reducing resistance risks. Further clinical validation is needed for widespread adoption in treating infections and managing chronic wounds.

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Area of Science:

Biomedical Engineering
Drug Delivery Systems
Infectious Diseases

Background:

Traditional antibiotic delivery methods often result in systemic toxicity and limited bioavailability.
Transdermal microneedle (MN) arrays present a novel approach to overcome these limitations by bypassing skin barriers.
Minimizing antibiotic resistance is a critical global health challenge addressed by improved delivery strategies.

Purpose of the Study:

To review advanced microneedle (MN) systems for transdermal antibiotic delivery.
To highlight innovations in MN design, nanomaterial integration, and preclinical efficacy.
To assess the potential of MN technology in combating antibiotic resistance and managing chronic wounds.

Main Methods:

Review of current literature on various microneedle (MN) array types (solid, coated, hollow, dissolvable, stimuli-responsive).
Analysis of design innovations and nanomaterial applications in MN systems.
Evaluation of preclinical data on MN efficacy against specific infections, including methicillin-resistant Staphylococcus aureus (MRSA).

Main Results:

Advanced MN systems demonstrate enhanced antibiotic penetration and targeted delivery.
Integration of nanomaterials and innovative designs improve MN performance.
Preclinical studies show significant efficacy against challenging infections like MRSA.

Conclusions:

Microneedle (MN) technology offers a minimally invasive and effective strategy for transdermal antibiotic delivery.
Overcoming challenges in scalability and demonstrating real-world efficacy are crucial for clinical adoption.
Further clinical validation is essential to establish MN systems as mainstream solutions for antibiotic resistance and wound management.