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Updated: Sep 19, 2025

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3D-printed polymeric biomaterials in bone tissue engineering.

Tianyi Xia1, Xianglong Zhou1, Haoran Zhou1

  • 1Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.

Biomedical Materials (Bristol, England)
|June 5, 2025
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Summary

This review explores 3D-printed polymers for bone tissue engineering (BTE). It covers bone regeneration, material selection, 3D printing techniques, and functional design for BTE applications.

Keywords:
3D printingbiomaterialsbone regenerationbone tissue engineeringpolymers

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Science

Background:

  • Polymers, derived from natural or synthetic sources, possess unique properties making them valuable in biomedical applications.
  • Bone tissue engineering (BTE) utilizes advanced materials and techniques to regenerate bone defects.
  • Three-dimensional (3D) printing offers precise fabrication of complex structures using polymers for BTE.

Purpose of the Study:

  • To provide a comprehensive overview of 3D-printed polymeric biomaterials for bone tissue engineering.
  • To discuss the fundamental aspects of bone regeneration relevant to biomaterial design.
  • To explore polymer selection, 3D printing technologies, and functional design considerations in BTE.

Main Methods:

  • Literature review of polymers, 3D printing technologies, and bone regeneration principles.
  • Analysis of functional properties and design strategies for 3D-printed polymeric biomaterials.
  • Synthesis of current research, challenges, and future prospects in the field.

Main Results:

  • Polymers offer versatile properties suitable for BTE scaffolds.
  • 3D printing enables customized fabrication of complex polymeric structures for BTE.
  • Functional design of these materials is crucial for successful bone regeneration.

Conclusions:

  • 3D-printed polymeric biomaterials represent a promising approach for bone tissue engineering.
  • Further research is needed to address challenges in material optimization and clinical translation.
  • Future directions include advanced functionalization and integration with biological cues for enhanced BTE outcomes.