Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
Stomach pH Regulation01:21

Stomach pH Regulation

The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
Gross Anatomy of the Stomach01:16

Gross Anatomy of the Stomach

The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
Stomach Histology01:26

Stomach Histology

The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deaths due to isolated extremity gunshot wounds in children and young adults in the USA.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2026
Same authorSame journal

Long-term Obstetric and Gynecologic Care for Patients with Anorectal Malformations.

Journal of pediatric surgery·2026
Same authorSame journal

Post-pubertal Gynecologic Evaluation and Management of Patients with Anorectal Malformations.

Journal of pediatric surgery·2026
Same authorSame journal

Gynecologic Care in Patients with Anorectal Malformations: A Primer and Call to Action.

Journal of pediatric surgery·2026
Same author

Pre-pubertal Gynecologic Evaluation and Management of Patients with Anorectal Malformations.

Journal of pediatric surgery·2026
Same authorSame journal

Methods of gynecologic evaluation for patients with anorectal malformations.

Journal of pediatric surgery·2026

Related Experiment Video

Updated: Jul 25, 2026

Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.6K

Simple vs. Complex Gastroschisis Outcomes: 30-Year Multicenter Review.

Andreina Giron1, Peter T Yu2, John Schomberg2

  • 1Division of Pediatric General & Thoracic Surgery, Children's Hospital Orange County, Orange, CA, USA; Department of Surgery, Montefiore Medical Center, Bronx, NY, USA.

Journal of Pediatric Surgery
|June 5, 2025
PubMed
Summary

Complex gastroschisis (CG) is linked to higher rates of prematurity, necrotizing enterocolitis, and longer hospital stays compared to simple gastroschisis (SG). However, survival to discharge remains similar for both conditions.

Keywords:
Complex gastroschisisGastroschisis outcomesParental counselingSimple gastroschisis

More Related Videos

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair
05:15

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Published on: December 23, 2022

6.7K
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
03:32

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

Published on: December 27, 2024

953

Related Experiment Videos

Last Updated: Jul 25, 2026

Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.6K
Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair
05:15

Application of a New Mesh Fixation Method in Laparoscopic Incisional Hernia Repair

Published on: December 23, 2022

6.7K
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
03:32

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

Published on: December 27, 2024

953

Area of Science:

  • Neonatal surgery
  • Pediatric gastroenterology
  • Congenital anomalies

Background:

  • Gastroschisis, a congenital abdominal wall defect, has seen increasing prevalence globally.
  • Understanding long-term outcomes and factors differentiating simple (SG) from complex gastroschisis (CG) remains crucial.
  • Previous research indicates disparities in morbidity and mortality between SG and CG, but lacks extended data.

Purpose of the Study:

  • To evaluate clinical outcomes in gastroschisis over a 30-year period.
  • To compare outcomes between simple gastroschisis (SG) and complex gastroschisis (CG).
  • To hypothesize and test for differences in clinical outcomes between SG and CG.

Main Methods:

  • Retrospective review of Cerner Real World Data from 1998-2022.
  • Classification of gastroschisis into simple (SG) and complex (CG) based on operative procedures and comorbidities.
  • Analysis of primary endpoints including mortality, length of stay (LOS), ventilator use, necrotizing enterocolitis (NEC), intestinal dysmotility, and gastroesophageal reflux disease (GERD).

Main Results:

  • The cohort included 331 neonates: 255 SG and 76 CG.
  • Complex gastroschisis (CG) demonstrated higher rates of prematurity, necrotizing enterocolitis (NEC), and intestinal dysmotility.
  • CG was associated with significantly increased length of stay (LOS) and decreased routine discharge rates, though survival to discharge was comparable to SG.

Conclusions:

  • This extensive retrospective study confirms significant outcome disparities between simple (SG) and complex gastroschisis (CG).
  • Findings underscore the importance of differentiating between SG and CG for patient management and family counseling.
  • Healthcare providers should counsel families on potential outcomes to ensure optimal preparation for newborns with gastroschisis.