Current concepts and controversies in post-neoadjuvant breast pathology

This review aims to be a helpful guide for pathologists in summarizing the current concepts and controversies in the reporting of post-neoadjuvant breast carcinoma specimens. It is structured to chronologically detail the relevant points from the initial diagnosis in the pretreatment biopsy to the gross and microscopic evaluation of the posttreatment surgical specimen, with pertinent digressions related to imaging, representative sampling, staging systems, prognostic biomarker testing, and clinical implications of reporting residual disease.