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Current concepts and controversies in post-neoadjuvant breast pathology
Gregory R Bean1, Benjamin C Calhoun2
1Department of Pathology, Stanford University, Palo Alto, CA, USA.
Human Pathology
|June 5, 2025
Summary
This review guides pathologists on reporting post-neoadjuvant breast carcinoma specimens. It covers diagnosis, gross and microscopic evaluation, and the clinical implications of residual disease.
Area of Science:
- Pathology
- Oncology
Background:
- Neoadjuvant therapy is increasingly used for breast carcinoma.
- Accurate reporting of post-neoadjuvant specimens is crucial for patient management.
Purpose of the Study:
- To provide a comprehensive guide for pathologists on reporting post-neoadjuvant breast carcinoma specimens.
- To summarize current concepts and controversies in this area.
Main Methods:
- Review of current literature and guidelines.
- Chronological detailing of the diagnostic and evaluation process.
- Inclusion of related topics such as imaging and biomarker testing.
Main Results:
- Discussion of challenges in evaluating treatment response.
- Highlighting key areas for accurate gross and microscopic assessment.
- Emphasis on the importance of standardized reporting.
Conclusions:
- Standardized reporting of post-neoadjuvant specimens improves patient care.
- Pathologists play a vital role in assessing treatment response and residual disease.
- Further research is needed to address ongoing controversies.
