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Updated: Sep 19, 2025
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Beraprost sodium ameliorates cognitive impairment by promoting oligodendrocyte precursor cell proliferation and
Mengsha Hu1, Bingsong Xu1, Linzhi Ge1
1Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China; Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Abstract:
Chronic cerebral hypoperfusion (CCH) leads to white matter injury (WMI), a key contributor to the development of vascular cognitive impairment (VCI). Beraprost sodium (BPS) is a chemically stable and orally active prostaglandin I2 (PGI2) analog, while the role and mechanism of BPS in VCI have not been well understood. In this study, we used a mouse model of bilateral carotid artery stenosis (BCAS mice) and demonstrated that BPS treatment facilitated the proliferation and differentiation of oligodendrocyte precursor cells (OPCs), potentially via PDGFR-α pathway modulation. This intervention promoted remyelination and attenuated WMI and cognitive dysfunction in BCAS mice. Collectively, our results suggested that BPS mitigates chronic ischemic WMI by targeting OPC development, providing a potential therapeutic avenue for VCI.
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