Related Experiment Video
Updated: Sep 19, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Cancer Risk Associated With Radiation Doses Used for CT Scans in Pediatric and General Hospitals
Malini Mahendra1,2, Matthew N Malekhedayat3, Philip W Chu3
1Department of Pediatrics, University of California, San Francisco, California.
Computed tomography (CT) radiation doses vary by hospital type, leading to an estimated 1200 excess cancers annually in children. Optimizing CT scan protocols is crucial for reducing pediatric cancer risks.
Area of Science:
- Radiology
- Pediatric Imaging
- Radiation Oncology
Background:
- Computed tomography (CT) is a vital diagnostic tool in pediatric care.
- Radiation exposure from CT scans is a concern due to potential long-term health risks, including cancer.
- Variations in CT radiation dosing across different healthcare settings may impact patient outcomes.
Purpose of the Study:
- To document radiation doses for common CT scans in pediatric patients across various hospital types.
- To evaluate the impact of observed dose variations on estimated lifetime cancer risks in children.
Main Methods:
- A retrospective cohort study analyzed 192,185 CT scans from a large CT dose registry.
- Scans were categorized by body region, clinical indication, and dose levels.
- Radiation doses were compared between hospital types, and excess cancer risks were calculated using the National Cancer Institute Cancer Risk calculator.
Main Results:
- Pediatric hospitals showed 20-30% lower doses for routine head and abdomen/pelvis CT in older children (12-<21 years).
- For younger children (<12 years), pediatric hospitals had lower head CT doses but higher chest CT doses (30-100%).
- An estimated 5500 excess cancers are linked to annual pediatric CT radiation, with 1200 attributed to dose differences.
Conclusions:
- Pediatric CT radiation doses contribute to an estimated 5500 future cancers annually.
- Dose variations account for approximately 1200 excess radiation-associated cancers.
- Further research is needed to understand dose variation causes and ensure optimal pediatric CT protocols.
Related Concept Videos
Radiological Investigation I: X-ray and CT
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Biological Effects of Radiation
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

