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Published on: April 10, 2018
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T Cell Responses During Dengue Infection.
Luciana Barros de Arruda1, Ernesto T A Marques2,3
1Laboratório de Genética e Imunologia das Infecções Virais, Depto de Virologia, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. arruda@micro.ufrj.br.
Current Topics in Microbiology and Immunology
|June 5, 2025
Summary
Understanding T cell immunity is crucial for dengue virus (DENV) infection. This chapter explores T cell responses, their role in protection and disease, and implications for vaccine development.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Dengue virus (DENV) infection involves four serotypes, complicating immune response understanding.
- While antibodies are studied, T cell immunity also plays a role in DENV resolution, memory, and potentially immunopathology.
- Subsequent infections with different DENV serotypes increase severe disease risk.
Purpose of the Study:
- To review T cell-specific DENV epitopes and the activated T cell repertoire.
- To discuss the role of distinct T cell subtypes in protection, memory, and immunopathology.
- To highlight the importance of T cell-mediated immunity in dengue pathogenesis and vaccine development.
Main Methods:
- Review of findings on T cell-specific DENV epitopes.
- Analysis of the activated T cell repertoire in dengue.
- Discussion of distinct T cell subtypes and their functions.
Main Results:
- T cell immunity contributes to infection resolution and long-term memory.
- Altered T cell responses can exacerbate dengue disease severity.
- Specific T cell responses are linked to protection and memory.
Conclusions:
- Understanding T cell mechanisms is vital for dengue pathogenesis research.
- Identifying T cell markers is critical for dengue vaccine efficacy assessment.
- T cell-mediated immunity must be considered in dengue immunization strategies.
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