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Natural Products and lncRNAs in Renal Cell Carcinoma: Emerging Therapeutic Approaches

Ahmed S Doghish1,2, Mai A Abd-Elmawla3, Nora M Aborehab4

  • 1Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Egypt.

The Journal of Gene Medicine
|June 6, 2025
PubMed

Insights

Long noncoding RNAs (lncRNAs) are key in renal cell carcinoma (RCC) progression and treatment resistance. Natural compounds show promise for targeting lncRNAs in novel RCC therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Renal cell carcinoma (RCC) is a prevalent cancer with poor outcomes, often resistant to conventional treatments.
  • Long noncoding RNAs (lncRNAs) are implicated in RCC pathogenesis, influencing key processes like proliferation, metastasis, and therapeutic resistance.
  • Existing therapies for advanced RCC are limited, necessitating exploration of novel therapeutic targets and strategies.

Purpose of the Study:

  • To review the biogenic pathways and functions of lncRNAs in renal cell carcinoma (RCC).
  • To elucidate the role of lncRNAs in RCC pathophysiology, posttranscriptional regulation, and therapeutic resistance.
  • To explore the potential of natural compounds in targeting lncRNA-mediated pathways for novel RCC treatment strategies.

Main Methods:

  • Literature review of studies on lncRNAs in renal cell carcinoma (RCC).
  • Analysis of lncRNA involvement in critical cellular pathways (EMT, proliferation, apoptosis, angiogenesis, metastasis).
  • Examination of lncRNA roles in chemoresistance and radioresistance in RCC.
  • Investigation into natural compounds (curcumin, quercetin, resveratrol) targeting lncRNA pathways.

Main Results:

  • lncRNAs are crucial molecular mediators in RCC, regulating key oncogenic pathways.
  • lncRNAs significantly contribute to chemoresistance and radioresistance in renal cell carcinoma (RCC).
  • Natural compounds demonstrate potential for targeting lncRNA-mediated pathways in RCC.

Conclusions:

  • lncRNAs represent significant molecular players in renal cell carcinoma (RCC) development and progression.
  • Targeting lncRNAs with natural compounds offers a promising avenue for developing novel and personalized RCC therapies.
  • Further research into lncRNA-targeted therapies could improve treatment outcomes for renal cell carcinoma (RCC) patients.
Keywords:
long noncoding RNAs (lncRNAs)natural productsrenal cell carcinoma (RCC)signaling pathwaystherapy resistance

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