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3D-Printed Tantalum Scaffolds Regulates the SDF-1α/CXCR4 Signaling Axis through Spatial Configuration To Enhance the
Yifan Wu1,2, Ran Wei1,2, Jie Jiang1,2
1Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing 100044, People's Republic of China.
None:
Osteoporosis with large bone defects lacks effective reconstruction methods. Consequently, to improve reconstruction efficiency, a deeper understanding of the molecular mechanisms of osteoporotic bone defect repair is a "bottleneck problem" that needs to be resolved. Via proliferation, adhesion, osteogenic differentiation, and animal experiments, we found that 3D-printed tantalum (Ta) scaffolds could upregulate the expression of TNF-α, an upstream signal of SDF-1α/CXCR4, and that the expression of TNF-α could also differ with changes to the scaffolds' spatial configuration. Through in vitro and in vivo experiments, this study demonstrated that Ta could upregulate the SDF-1α/CXCR4 signaling pathway through its spatial structure, thereby promoting the repair of osteoporotic bone defects. These research outcomes present an approach for treating osteoporotic bone defects and establish a theoretical foundation for manufacturing 3D-printed Ta prosthetic structures.
