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Related Experiment Videos

[Cefoperazone: microbiological, kinetic and clinical studies].

F Di Nola, M L Soranzo, E Capra

    Minerva Medica
    |October 13, 1985
    PubMed
    Summary

    Cefoperazone demonstrated superior in vitro activity against gram-negative bacteria compared to piperacillin and mezlocillin. This antibiotic achieved effective plasma concentrations and high clinical cure rates, despite a notable disulfiram-like effect.

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    Area of Science:

    • Pharmacology
    • Microbiology
    • Clinical Medicine

    Background:

    • Gram-negative bacterial infections pose a significant clinical challenge.
    • Existing antibiotics like piperacillin and mezlocillin have limitations in efficacy or resistance patterns.
    • Cefoperazone is a third-generation cephalosporin with broad-spectrum activity.

    Purpose of the Study:

    • To evaluate the in vitro activity of cefoperazone against gram-negative bacteria.
    • To assess the pharmacokinetic profile of cefoperazone after intravenous administration.
    • To determine the clinical efficacy and safety of cefoperazone in treating infections.

    Main Methods:

    • In vitro susceptibility testing of cefoperazone, piperacillin, and mezlocillin against gram-negative bacteria.

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  • Pharmacokinetic analysis of cefoperazone plasma concentrations following 1g intravenous bolus administration.
  • Clinical evaluation of patient outcomes, including cure rates and adverse events.

    • Main Results:

    • Cefoperazone exhibited greater in vitro potency against tested gram-negative bacteria than piperacillin or mezlocillin.
    • Intravenous cefoperazone achieved high and sustained plasma concentrations for at least 8 hours.
    • Renal and biliary excretion accounted for the majority of cefoperazone elimination (33.2% renal).
    • A high clinical cure rate of 97.22% (35/36 patients) was observed.
    • An 18.18% incidence of disulfiram-like reactions was reported.

    Conclusions:

    • Cefoperazone is a highly effective antibiotic against susceptible gram-negative bacteria.
    • The pharmacokinetic profile supports an 8-hour dosing interval for cefoperazone.
    • Cefoperazone demonstrates significant clinical efficacy in treating bacterial infections.
    • The disulfiram-like effect is a notable adverse event requiring clinical consideration.