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Microalbuminuria Is Associated With Left Ventricular Systolic Function in Newly Diagnosed Hypertensive Patients

Selim Aydemir1, Sidar Şiyar Aydın2, Onur Altınkaya1

  • 1Department of Cardiology, University of Health Sciences, Erzurum City Hospital, Erzurum, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|June 6, 2025
PubMed

Insights

Hypertension treatment improved cardiac function, with decreased urinary albumin creatinine ratio (UACR) linked to better left ventricular global longitudinal strain (LVGLS). UACR can monitor treatment effectiveness in hypertensive patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Hypertension (HT) is a major global cardiovascular (CV) risk factor, often leading to cardiac dysfunction.
  • Urinary albumin creatinine ratio (UACR) indicates microalbuminuria and predicts adverse CV events in HT patients.

Purpose of the Study:

  • To investigate the relationship between UACR and cardiac function in newly diagnosed HT patients.
  • To assess if UACR changes correlate with cardiac function improvements after treatment.

Main Methods:

  • Prospective study of 104 newly diagnosed HT patients treated with ACEIs.
  • Collected urine samples, 24-h BP monitoring, echocardiography (TTE), and LVGLS via speckle-tracking before and after 3 months of treatment.
  • Linear regression analyzed UACR and cardiac parameter relationships.

Main Results:

  • Treatment reduced blood pressure and UACR significantly.
  • Decreased UACR showed a significant association with improved LVGLS.
  • Microalbuminuria reduction correlated independently with LVGLS improvement.

Conclusions:

  • A significant link exists between microalbuminuria (UACR) and LVGLS.
  • Blood pressure control and UACR reduction in HT patients improve cardiac function.
  • UACR is a potentially valuable marker for monitoring LV systolic function improvement.
Abstract

Keywords:
hypertensionleft ventricular global longitudinal strainmicroalbuminuriaspeckle‐tracking echocardiographyurinary albumin creatinine ratio

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