Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

198
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
198
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical evaluation of communication brain computer interfaces in amyotrophic lateral sclerosis: a landscape analysis.

Frontiers in human neuroscience·2026
Same author

Connectivity biases generate a learning hierarchy in the <i>Drosophila</i> mushroom body.

bioRxiv : the preprint server for biology·2025
Same author

Inhibitory Neurons Marked by the Connectivity Molecule Kirrel3 Regulate Memory Precision.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.

Research square·2025
Same author

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.

bioRxiv : the preprint server for biology·2025
Same author

An <i>Intranet</i> of Things approach for adaptable control of behavioral and navigation-based experiments.

eLife·2025

Related Experiment Video

Updated: Jun 16, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K

Hippocampal time cell dynamics evolve with learning to reflect cognitive demands.

Erin R Bigus1, John C Bowler2, Dua Azhar2

  • 1Interdepartmental PhD Program in Neuroscience, University of Utah.

Biorxiv : the Preprint Server for Biology
|June 6, 2025
PubMed
Summary

Hippocampal time cells create cognitive maps of time, evolving with experience. Their activity dynamically reflects how animals learn and use temporal relationships, aiding context discrimination in tasks.

More Related Videos

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

15.9K
Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.8K

Related Experiment Videos

Last Updated: Jun 16, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

15.9K
Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.8K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Biology

Background:

  • The hippocampus is crucial for forming cognitive maps, representing external world knowledge.
  • Hippocampal time cells are hypothesized to encode the temporal structure of experiences (temporal context).
  • It's unclear if time cell activity changes with learning to reflect improved understanding of temporal relationships.

Purpose of the Study:

  • To investigate if hippocampal time cells exhibit learning dynamics related to temporal structure acquisition.
  • To determine how time cell activity evolves as animals learn to discriminate temporal contexts.
  • To explore the role of time cells in utilizing temporal relationships for cognitive tasks.

Main Methods:

  • A behavioral paradigm with a shaping curriculum was used to teach mice temporal structure.
  • Two-photon calcium imaging recorded activity of large neuronal populations in the CA1 region.
  • Mice were trained on a temporal Delayed Non-Match to Sample (tDNMS) task.

Main Results:

  • Time cells were present early in training and showed evolving activity patterns with experience.
  • Single-cell and population-level dynamics of time cells changed throughout the learning curriculum.
  • Time cell dynamics adapted to reflect context generalization versus discrimination by the mice.

Conclusions:

  • Hippocampal CA1 time cells represent temporal context and its utilization during learning.
  • Time cell activity evolves to reflect the cognitive demands of understanding temporal relationships.
  • These findings suggest time cells contribute to the hippocampus's function as a cognitive map for temporal information.