Related Experiment Video
Updated: Jan 18, 2026
07:42
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
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Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in
Biorxiv : the Preprint Server for Biology
|June 6, 2025
Summary
A novel long non-coding RNA, Prostate Locus of Uncharacterized Transcript Outlier 201 (PLUTO-201), drives aggressive prostate cancer. PLUTO-201 promotes metastasis and poor survival by regulating steroid biosynthesis and immune evasion.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Factors driving aggressive prostate cancer remain poorly understood.
- Lack of effective therapeutic targets and prognostic biomarkers for prostate cancer progression.
Purpose of the Study:
- Identify novel molecular drivers of aggressive prostate cancer.
- Investigate the role of PLUTO-201 in prostate cancer progression and metastasis.
Main Methods:
- Comprehensive whole-genome transcriptome analysis of 1,567 prostate cancer patients.
- In vitro and in vivo preclinical models of prostate cancer.
- Analysis of PLUTO-201 interaction with hnRNPK.
Main Results:
- Identified PLUTO-201 as a novel lncRNA strongly associated with metastasis and poor survival.
- PLUTO-201 overexpression promotes proliferation, invasion, and metastasis.
- PLUTO-201 regulates steroid biosynthesis and MHC class I expression, impacting androgen deprivation and T cell cytotoxicity.
Conclusions:
- PLUTO-201 is a critical driver of aggressive prostate cancer phenotypes.
- PLUTO-201 represents a potential therapeutic target and prognostic biomarker for prostate cancer.
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