Role and potential mechanisms of miR‑100 in different diseases (Review)

Area of Science:

• Molecular Biology
• Biochemistry
• Genetics

Background:

• MicroRNAs (miRNAs) are increasingly recognized for their roles in disease pathogenesis.
• miR-100, part of the miR-99 family, is implicated in numerous pathophysiological processes.
• Dysregulation of miR-100 is observed in both non-cancerous diseases and various cancers.

Purpose of the Study:

• To review the literature on miR-100 in non-cancerous diseases and cancer.
• To investigate the mechanisms of action of miR-100 across different disease contexts.
• To evaluate the potential of miR-100 as a diagnostic biomarker and its role in cancer drug resistance.

Main Methods:

• Comprehensive literature search and review of existing studies on miR-100.
• Analysis of miR-100's involvement in cellular processes like proliferation, invasion, migration, and apoptosis.
• Examination of miR-100's function in non-cancerous conditions and its impact on tumor development and progression.

Main Results:

• miR-100 significantly influences the pathogenesis of various non-cancerous diseases.
• In cancer, miR-100 affects critical processes including cell proliferation, invasion, migration, and apoptosis.
• Evidence suggests miR-100's potential as a diagnostic biomarker and its involvement in therapeutic resistance.

Conclusions:

• miR-100 is a key regulator in diverse disease mechanisms, both cancerous and non-cancerous.
• Understanding miR-100's functions is vital for developing novel diagnostic and therapeutic strategies.
• Further research into miR-100's role in drug resistance could inform treatment advancements.