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Updated: Jul 25, 2026

Bone Conditioned Medium: Preparation and Bioassay

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Immune microenvironment modulation for treating inflammatory periodontal bone defects using a dynamic dual-responsive

Jiufan Yao^1,2,3, Chi Zhang^1,2,3, Chuanying Yu^1,2,3

¹Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong Province, 510055, P. R. China. liwch57@mail.sysu.edu.cn.

Journal of Materials Chemistry. B

|June 6, 2025

Summary

A novel hydrogel loaded with sinapic acid (SA) effectively treats periodontitis by controlling inflammation and promoting bone regeneration. This advanced material offers a promising solution for periodontal bone defects.

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Area of Science:

Biomaterials Science
Periodontology
Immunology

Background:

Periodontitis is a bacterial-induced chronic inflammatory disease impacting tooth-supporting structures.
Effective treatment requires plaque control and maintaining local immune balance for bone regeneration.

Purpose of the Study:

To develop a pH/ROS dual-responsive hydrogel system (CDFBCS@SA) for controlled sinapic acid (SA) release.
To evaluate the hydrogel's efficacy in improving the periodontal inflammatory microenvironment and promoting bone regeneration.

Main Methods:

Fabrication of a dynamic cross-linked hydrogel using modified carboxymethyl cellulose (CMCDA) and carboxymethyl chitosan (CCS).
Loading of sinapic acid (SA), a natural phenolic compound with antibacterial and immunomodulatory properties.
In vitro and in vivo assessments of the hydrogel's effects on inflammatory factors, oxidative stress, macrophage polarization, and bone regeneration.

Main Results:

The CDFBCS@SA hydrogel demonstrated controlled, long-term release of SA.
The system effectively modulated the periodontal inflammatory microenvironment by reducing inflammation and oxidative stress.
Significant enhancement of periodontal bone defect regeneration was observed in vivo.

Conclusions:

The pH/ROS dual-responsive hydrogel system offers a promising strategy for periodontal regenerative therapy.
Controlled SA release from the hydrogel aids in restoring local immune homeostasis.
This approach shows potential for treating periodontal bone defects by promoting bone regeneration.