Related Experiment Video
Updated: Jan 18, 2026
08:51
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
9.7K
Localized scleroderma: multiparametric MRI with diffusion-weighted imaging and gadolinium-based perfusion imaging for
Alex Iancau1, Sarah Attia1, Priya Sarlashkar1
1Medical School, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Skeletal Radiology
|June 6, 2025
Summary
Multiparametric MRI (MPMRI) shows promise for assessing morphea activity. Perfusion and delayed enhancement correlate with active disease, offering a valuable tool beyond conventional MRI for evaluating morphea.
Area of Science:
- Radiology
- Medical Imaging
- Dermatology
Background:
- Conventional MRI has limitations in assessing morphea disease activity.
- Multiparametric MRI (MPMRI) offers advanced imaging techniques for evaluation.
Purpose of the Study:
- To explore the utility of MPMRI in assessing morphea disease activity.
- To correlate MRI findings with clinical assessment of morphea.
Main Methods:
- Retrospective study of 35 morphea patients using MRI with diffusion-weighted imaging (DWI) and perfusion techniques.
- Independent assessment of lesion extent and activity by three radiologists.
- Correlation of MRI findings with Physician Global Assessment (PGA).
Main Results:
- Active morphea lesions showed increased perfusion and delayed enhancement (71% of cases).
- Active lesions had significantly higher PGA scores compared to inactive lesions.
- Diffusion-weighted imaging (DWI) showed trends but had poor inter-reader reliability for ADC values.
Conclusions:
- MPMRI is a promising tool for assessing morphea extent and activity, correlating with clinical evaluation.
- Perfusion and delayed enhancement are key indicators of active morphea.
- DWI's current utility in morphea assessment is limited due to variability.
Related Concept Videos
01:17Assessment of Diffusion and Perfusion
1.6K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.6K
01:24Magnetic Resonance Imaging
9.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
9.1K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
365
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
365