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Pro-ferroptotic lipids as key control points for caveola formation and disassembly

Yeping Wu1, Ye-Wheen Lim1, Kerrie-Ann McMahon1

  • 1Institute for Molecular Bioscience, the University of Queensland, Brisbane, QLD 4072, Australia.

Cell Reports
|June 6, 2025
PubMed
Summary

Specific lipids regulate caveola formation and disassembly. Omega-6 polyunsaturated fatty acids (PUFAs) promote caveolae, while their oxidation triggers disassembly during lipid peroxidation, linking caveola dynamics to ferroptosis.

Keywords:
ACSL4CP: Cell biologyMUFAPUFAcCaveolaefFerroptosislLipidspPlasmalogens

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