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Liquid metal based electroconductive artificial periosteum boosts bone regeneration.

Yang Zou1,2, Yuxin Duan1,2, Mengran Wang3

  • 1School of Resources and Environment, Wuhan Textile University, Wuhan, P. R. China.

Journal of Biomaterials Science. Polymer Edition
|June 6, 2025
PubMed
Summary

This study developed an electroconductive artificial periosteum using liquid metal. Combined with electrical stimulation, it enhances bone stem cell differentiation and promotes bone defect repair, offering a promising approach for bone regeneration.

Keywords:
Bone defect repairartificial periosteumbone marrow mesenchymal stem cellselectrical stimulationliquid metal

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • The periosteum is vital for bone growth and repair.
  • Artificial periosteum development is of significant interest.
  • Electroconductive materials are crucial for electrical stimulation-enhanced bone regeneration.

Purpose of the Study:

  • To create a liquid metal-based electroconductive artificial periosteum.
  • To investigate its effect on osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) with electrical stimulation (ES).
  • To evaluate its efficacy in repairing large bone defects when integrated into a decellularized bone matrix (DBM) scaffold.

Main Methods:

  • Fabrication of an electroconductive liquid metal (LM) based artificial periosteum scaffold.
  • In vitro assessment of LM periosteum with ES on BM-MSC osteogenic differentiation.
  • In vivo evaluation of LM periosteum-coated DBM scaffolds with ES in a rabbit radial defect model.

Main Results:

  • The electroconductive artificial periosteum exhibited good biocompatibility.
  • Combined with ES, it significantly enhanced BM-MSC osteogenic differentiation.
  • The electroconductive bone repair scaffold promoted bone integration and regeneration in large bone defects.

Conclusions:

  • LM-based electroconductive artificial periosteum is a viable strategy for bone regeneration.
  • The combination of this scaffold with ES effectively promotes osteogenic differentiation and bone defect repair.
  • This technology offers a promising reference for future bone regeneration applications.