Related Experiment Video
Updated: Sep 19, 2025
08:53
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
632
Behavioral and Neural correlates of Post-STROKE Fatigue: A randomized controlled trial protocol.
Kuan-Chun Liao1, Isabelle Christian1, Jill Stewart2
1School of Physical Therapy, Texas Woman's University, Dallas, Texas, United States of America.
Plos One
|June 6, 2025
Summary
This study investigates transcranial direct current stimulation (tDCS) for post-stroke fatigue (PSF). Five daily sessions of tDCS may offer a promising intervention for managing PSF symptoms and understanding its neurophysiological effects.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Clinical Trials
Background:
- Post-stroke fatigue (PSF) is a common and debilitating condition with limited effective treatments.
- Transcranial direct current stimulation (tDCS) shows potential for PSF management, but its lasting effects and mechanisms remain unclear.
Purpose of the Study:
- To determine the behavioral and neurophysiological effects of a five-day course of tDCS on post-stroke fatigue.
- To investigate the impact of tDCS on motor cortex excitability and fronto-striato-thalamic network connectivity.
Main Methods:
- A double-blind, randomized controlled trial involving 32 participants with post-stroke fatigue.
- Participants received either anodal tDCS or sham tDCS applied to the ipsilesional primary motor cortex (M1) for five consecutive days.
- Outcomes assessed included the Fatigue Severity Scale (FSS), motor cortex excitability via TMS, and resting-state fMRI.
Main Results:
- This section is to be filled once the study is completed and results are available.
Conclusions:
- tDCS presents a potential therapeutic avenue for post-stroke fatigue.
- Further research is needed to elucidate the long-term efficacy and underlying mechanisms of tDCS in managing PSF.
