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Updated: Sep 19, 2025

Digital PCR-based Competitive Index for High-throughput Analysis of Fitness in Salmonella
Published on: May 13, 2019
Endogenous competition and the underrealized reproduction of infectious diseases
Peng Huang1,2, Zack W Almquist3,4, Carter T Butts5,6,7,8
1Department of Sociology, University of Georgia, Athens, GA 30602.
Abstract:
Scientific inquiry about the transmissibility of infectious diseases is largely based on the basic reproduction number ([Formula: see text]) and its derivations. This paper describes a mechanism overlooked in most conventional analyses, in which a disease can endogenously "compete" with itself when multiple infectious individuals race to infect the same susceptible individual, thereby reducing the effective reproductive rate. Utilizing an empirically calibrated network epidemiological model of wild-type COVID-19 diffusion in its early pandemic, we show that the mechanism would be expected to reduce its reproductive rate by an average of 39%. Simulation experiments further identify different types of endogenous competition mechanisms and their relative effect sizes. We highlight the incorporation of endogenous competition mechanism as a necessary step in realistically modeling the reproduction process of infectious diseases.
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