Need for speed: Mass photometry as a sample analysis tool for structural studies

  • 1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, New York, NY 10065, USA. Electronic address: lvostal@rockefeller.edu.

Abstract

Mass photometry (MP) is a label-free approach that measures the mass of single molecules in solution. Here, we discuss the principles of MP, example uses of the technique, and how it can be a valuable tool for structural biologists in streamlining cryoelectron microscopy (cryo-EM) pipelines.