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Diagnostic value of novel thrombus markers in COPD with deep venous thrombosis

Jiajun Huang1, Jie Huang2, Chunli Sun2

  • 1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, Guangdong, PR China.

The American Journal of the Medical Sciences
|June 6, 2025
PubMed

Insights

New thrombosis markers like thrombin antithrombin complex (TAT) and thrombomodulin (TM) show diagnostic value for predicting deep venous thrombosis (DVT) in chronic obstructive pulmonary disease (COPD) patients.

Area of Science:

  • Cardiology
  • Pulmonology
  • Hematology

Background:

  • Chronic obstructive pulmonary disease (COPD) patients are at increased risk for deep venous thrombosis (DVT).
  • Accurate diagnostic markers for DVT in COPD are crucial for timely intervention.
  • Traditional markers may not fully capture the thrombotic risk in this population.

Purpose of the Study:

  • To evaluate the diagnostic utility of novel thrombosis markers for DVT incidence in COPD patients.
  • To compare the efficacy of thrombin antithrombin complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC).

Main Methods:

  • A cohort of 98 COPD patients and 50 healthy controls were analyzed.
  • Patients were categorized into non-DVT and DVT groups.
  • Blood glucose, lipid profiles, and novel thrombosis markers were measured; ROC curve analysis was employed.

Main Results:

  • No significant differences in glucose or lipid profiles were observed between groups.
  • Fibrin degradation product (FDP) and D-dimer (D-D) were elevated in the DVT group.
  • TAT, PIC, TM, and t-PAIC levels were significantly higher in COPD patients with DVT. Combined TAT and TM showed high diagnostic efficacy (AUC 0.833, sensitivity 87.5%).

Conclusions:

  • Serum levels of TAT, PIC, TM, and t-PAIC are valuable diagnostic indicators for DVT in COPD patients.
  • The combination of TAT and TM offers superior diagnostic performance.
  • These markers can aid in the early detection and management of DVT in this high-risk group.
Abstract

Keywords:
Chronic obstructive pulmonary diseaseDeep vein thrombosisThrombus markers

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