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Giant Obstructing Left Ventricular Dedifferentiated Liposarcoma

Michele Dell'Aquila¹, Joost Ter Woorst², Ferdi Akca²

¹Department of Cardiothoracic Surgery, Catharina Ziekenhuis, Eindhoven, the Netherlands; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York, USA.

JACC. Case Reports

|June 6, 2025

Abstract:

We present the case of a 52-year-old woman diagnosed with new-onset atrial fibrillation due to an intracardiac mass found incidentally. She underwent successful surgical resection of an obstructing, paravalvular, dedifferentiated liposarcoma in the left ventricle and received a mitral valve replacement. The patient underwent adjuvant radiotherapy. Follow-up is ongoing.

Keywords:

cardiac dedifferentiated liposarcoma cardiac sarcoma cardiac tumor

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Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Keywords:

cardiac dedifferentiated liposarcoma cardiac sarcoma cardiac tumor

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