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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

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Giant Obstructing Left Ventricular Dedifferentiated Liposarcoma.

Michele Dell'Aquila¹, Joost Ter Woorst², Ferdi Akca²

¹Department of Cardiothoracic Surgery, Catharina Ziekenhuis, Eindhoven, the Netherlands; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York, USA.

JACC. Case Reports

|June 6, 2025

Summary

This summary is machine-generated.

A 52-year-old woman experienced new-onset atrial fibrillation caused by an incidentally discovered intracardiac mass. Surgical removal of the left ventricular dedifferentiated liposarcoma and mitral valve replacement were successful, followed by adjuvant radiotherapy.

Keywords:

cardiac dedifferentiated liposarcoma cardiac sarcoma cardiac tumor

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Area of Science:

Cardiology
Oncology
Cardiac Surgery

Background:

Intracardiac masses can present with diverse clinical manifestations.
Atrial fibrillation is a common arrhythmia that can be secondary to various cardiac conditions.
Dedifferentiated liposarcoma is a rare malignant mesenchymal tumor, with intracardiac presentation being exceptionally uncommon.

Purpose of the Study:

To report a rare case of new-onset atrial fibrillation secondary to an intracardiac dedifferentiated liposarcoma.
To highlight the diagnostic and therapeutic challenges associated with intracardiac tumors.
To emphasize the importance of considering rare etiologies in the differential diagnosis of cardiac masses.

Main Methods:

Case presentation of a 52-year-old female patient.
Diagnostic workup including incidental finding of an intracardiac mass.
Surgical resection of the mass and mitral valve replacement.
Adjuvant radiotherapy as part of the treatment protocol.

Main Results:

Successful surgical excision of a paravalvular, obstructing, dedifferentiated liposarcoma located in the left ventricle.
Mitral valve replacement was performed concurrently with tumor resection.
The patient tolerated adjuvant radiotherapy.
Ongoing follow-up to monitor for recurrence or complications.

Conclusions:

Dedifferentiated liposarcoma can present as an intracardiac mass causing significant cardiac dysfunction, such as atrial fibrillation.
Multidisciplinary management involving cardiac surgery, oncology, and potentially radiation oncology is crucial for optimal outcomes.
Complete surgical resection followed by adjuvant therapy may be beneficial in managing this rare malignancy.