Malaria-associated liver dysfunction: a forgotten challenge

Malaria-associated liver dysfunction (MALID) is a frequent yet understudied complication of severe malaria, characterized by increased liver enzyme levels, hyperbilirubinemia, and distinctive histopathological changes. Notably, MALID can persist despite antimalarial treatment and is strongly associated with morbidity and mortality. Given the central role of the liver in metabolism, immunity, and detoxification, MALID may profoundly impact the functionality of other organs and exacerbate overall disease severity. This review consolidates the current knowledge on MALID, emphasizing the need for further research to elucidate its underlying mechanisms and its interplay with other malaria-related complications. A deeper understanding of MALID could pave the way for improved treatment strategies and management of severe malaria cases.